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Retatrutide is described in the literature as an investigational triple-hormone receptor agonist with activity across all three pathways

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[1] [4] For patients with diabetes, additional monitoring for diabetic retinopathy is recommended, and those on insulin or sulfonylureas may require dose adjustments to prevent hypoglycaemia

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Compared to those who stayed on treatment, their: Heart risk rose 4% after 6 months It increased 14% after 1 year Heart risk climbed 22% after 2 years By that point, the earlier heart benefits were nearly gone