when was semaglutide approved FDA Warns on Certain Forms of Compounded Wegovy Pill Approved, Should Be

Oral Pathology & Medicine

Phase 2 trial data (published in New England Journal of Medicine, 2023 ): 24.2% average weight loss at 48 weeks with 12 mg dose 22.8% with 8 mg dose Placebo group lost 2.1% Most recent Phase 3 trial data (TRIUMPH-4, December 2025): 28.7% average weight loss at 68 weeks with 12 mg dose 26.4% with 9 mg dose 58.6% of participants on 12 mg achieved at least 25% weight loss 39.4% achieved at least 30% weight loss For context: These are the highest weight loss numbers reported in any clinical trial for a pharmacological obesity treatment

Precautions with Alcohol Alcohol-Semaglutide interaction has not been established

Incorrect dosing either reduces effectiveness or increases side effects unnecessarily