Peak effects cover the weekend, side effects are manageable over Friday and Saturday, and the end-of-week trough falls on the structured workdays when you need less pharmaceutical help
So far, the co-agonist drugs which have reached phase 2 trials have demonstrated an improved glycaemic profile with chronic administration
For this reason, if you have Hashimotos, you better make sure that your low thyroid symptoms are managed and controlled
Furthermore, in January 2025, the FDA approved semaglutide (Ozempic ) for reducing the risk of kidney failure and disease progression in patients with diabetes and chronic kidney disease (CKD), making it the first GLP-1 agent indicated for the treatment of CKD (Perkovic et al., 2024)
Patients should be aware that Ozempic is not a rapid-acting medication, and patience is required to experience its full benefits