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Individualized risk assessment, patient education, and prompt evaluation of persistent symptoms are essential to optimize treatment adherence and minimize potential clinical and economic consequences

this is thought to be through eventual damage of enteric nerves, altered intestinal muscle contractility and function, and disrupted intestinal microbiota (Yarandi 2014)

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For example, strains such as Lactobacillus casei and Lactobacillus paracasei suppress the production of pro-inflammatory cytokines by inhibiting the phosphorylation and subsequent degradation of IB, an endogenous inhibitor of NF-B

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