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The factors that lead to depletion of glutathione includes natural ageing process, or the external stressors that include chronic exposure to chemical toxins, cadmium exposure, alcohol use, smoking, pollution, strenuous aerobic activities, dietary factors, ultraviolet (UV) radiation exposure, tissue injury as from burns, ischemia, septic shock, surgery, drugs (such as acetaminophen and adriamycin)
Cell Reports (2019) 8
Protoplasma 245:8596 Foyer CH, Halliwell B (1976) The presence of glutathione and glutathione reductase in chloroplasts
Dupont et al
Nutrient Density Nutrition provides both the substrates and signaling context required for glutathione synthesis and mitochondrial resilience
