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Clinical trials show average systolic reductions of 3-5 mmHg, with larger improvements in patients who lose significant weight

Winter SC, Zorn EM, Vance WH

Options include: Metoclopramide : May help with delayed gastric emptying but should only be used for short courses (maximum 5 days) due to risk of neurological side effects Prochlorperazine : Can be effective for nausea and vomiting Cyclizine : An alternative that works through a different mechanism Ondansetron : Sometimes used but may cause constipation Domperidone : Used cautiously due to risk of heart rhythm problems (QT prolongation), particularly in older adults, those with heart conditions, or those taking other medications affecting heart rhythm For people with diabetes, it's important to follow sick-day rules if experiencing vomiting

She reviews the patients other medications and decides whether adding GLP-1s will do more harm than good

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