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Classic example with conjugation occurring after introduction of a nucleophilic site (phenol) Kamata et al Drug Metabolism Disposition 2006 Many compounds or drugs contain functional groups that can be directly conjugated and thus do notrequire Phase I metabolism to create handles (nucleophiles) for conjugation.Ciprofloxacin Propranolol BilirubinDiflunisal Acetaminophen Thyroxine (T4)Q

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For injectable or systemic research-compound use, the honest answer is: we do not have long-term human safety data

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