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General principles of compound absorption, distribution, metabolism and elimination as well as specific data from studies with Pycnogenol are summarized and discussed in this review

8.1.3 Network biology approach While pathway analysis highlights the dysregulated processes, network-based approaches extend this by mapping the interaction between genes, proteins, and molecular regulators within complex cellular systems, offering a complete holistic view of system-level changes (287, 288)

doi: 10.3389/fphar.2018.00388 Received 26 January 2018 Accepted 04 April 2018 Published 18 April 2018 Volume 9 - 2018 Edited by Olavi R

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Nowadays, clinical treatment for symptomatic RA faces numerous challenges