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As mentioned previously, pancreatic -cells express TLRs, which can modulate -cell viability, influence insulin homeostasis (122), and contribute to T1D initiation upon interaction with high-mobility group box 1 (HMGB1) (123)

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Perimenopause can start in the mid-30s to 50s and last for years or even a decade

PARPs in cancer PARPs or poly(ADP-ribose) polymerases are DNA repair nuclear proteins that can transfer ADP-ribose from the coenzyme NAD + to protein substrates