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Thus, given the accumulating evidence across species implicating this pathway as integral to aging and its associated diseases, the development of therapeutics aimed at modulating IGF-1 signaling in humans could prove highly effective as a translational tool to delay aging

We found that GLP-1R antagonism only partially blocked the glucose-lowering effects of tirzepatide (Extended Data Fig

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The influence of how hormones affect the brain has been a focus of research for years, laying the groundwork for including GLP-1s in this subject area