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In addition to iron-catalyzed free radical chain reactions, lipoxygenase (LOXs) can directly oxidize PUFAs and lipid-containing PUFAs in cell membranes, which are considered to have an essential role in ferroptosis [75, 80]

TB-500 calculations proceed similarly

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Furthermore, GGC itself may be capable of directly acting as an antioxidant by supporting the activity of the enzyme GSH peroxidase [20], which is responsible for eliminating hydrogen peroxide in the RPE [21]