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Peptide YY ameliorates cerulein-induced pancreatic injury in the rat

0.33g of the crude Boc-His (Trt) -Aib-OSu and 1g of Compound 2 obtained in example 3 were dissolved in 20mL of N, N-dimethylacetamide, and 2mL of N, N-diisopropylethylamine was added and reacted at room temperature for 8 hours to obtain Compound 4 having a purity of 77.23%, and a specific liquid phase diagram is shown in FIG

Avoid freeze-thaw cycling

High SCFAs = appetite control

The study found that use of DPP4 inhibitors, compared with other second- or third-line glucose-lowering drugs, was associated with a 77% increase in the risk of cholangiocarcinoma (HR 1.77 [95% CI 1.04, 3.01]), although the analysis only included 27 DPP4 inhibitor-exposed events