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To simulate dynamics of tax6 mutants, we nullified the calciumdependent term from equation 4 in the original model (by setting 1 and equations 14), we did not include explicit description of the voltagegated channels dynamics in AWA

Although not as prominently as in the case of primary stem cells, pre-osteoblastic cell lines such as MC3T3 and NH3T3 possess a certain degree of osteogenic capacity which can be regulated by the redox environment

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however it is actually a vitamin-like nutrient, similar in structure to the B Vitamins