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A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia
The documented mechanisms are: VEGF stimulation in dermal fibroblasts that supports the microvascular network feeding the follicle, collagen and glycosaminoglycan synthesis at the follicular basement membrane, anti-inflammatory signaling that calms the chronic micro-inflammation associated with androgenetic alopecia, and direct follicular signaling that extends the anagen growth phase
Tranexamic acid in melasma: Comparative evaluation of therapeutic efficacy of oral tranexamic acid versus its transepidermal administration
It has a distribution coefficient of 1.13310 5 and a pKa of 7.65
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