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Within each active month, the 5-days-on, 2-days-off schedule follows the same logic at the weekly level: it prevents tachyphylaxis (diminished response from constant exposure) while maintaining enough stimulus frequency to produce measurable visceral fat reduction

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Lower doses may be reasonable for some patients, but microdosing is still off-label, and the strongest evidence still comes from standard therapeutic dosing in populations with clinical obesity or metabolic disease, and many of the broader claims around low-dose use exceed what the evidence supports