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This observation likely reflects that MIA-induced OA primarily targets cartilage, whereas changes of the subchondral bone occur secondarily and can be influenced by factors such as mechanical loading, individual variability, and baseline bone status 52

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Spirulina was found to support antioxidant capacity by increasing superoxide dismutase (SOD) and catalase activities ( 3.5 The role of Spirulina in weight control Spirulina has shown positive effects on various physiological systems and may also play a role in obesity management

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