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The prescribing information notes that GLP-1 agonists have not been studied in patients with a history of pancreatitis, so whether to use them, and how closely to monitor, is an individualized decision rather than a blanket yes or no
While all three compounds stimulate growth hormone release via the GHS-R1a receptor, preclinical data from Raun et al
However, experts say patients discontinuing these medications may experience sharp metabolic shifts
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10.1016/j.tem.2021.02.002 177
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