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However, in glutathione synthetase deficiency, because the activity of gamma-glutamyl-cysteine synthetase is regulated via feedback inhibition by glutathione, gamma-glutamyl-cysteine and then L-5-oxoproline are overproduced, resulting in the metabolic acidosis and urinary excretion of this compound at levels several hundred-fold above normal (71
Its important for gastric bypass patients to talk to their doctors about the best way to get B12
however, it is not suitable for vegetarian or vegan diets
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Nephrol 26 , 261268 (2006)
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