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In a 6-month randomized, placebo-controlled trial in adults with BMI 28-34.9 (N=225), post-hoc factorial analysis found a B420-associated -4.0% difference in body fat mass (P=0.002), approximately 2.4 cm greater waist-circumference reduction, and roughly 300 kcal/day greater reduction in energy intake versus placebo
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The inflammatory response involves a complex interplay between leukocytes, including macrophages and lymphocytes, which release substances such as vasoactive amines, eicosanoids, and proinflammatory cytokines to mediate inflammation and promote tissue healing [86]
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