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With the gradual progression of atherosclerotic plaques, atherosclerosis will induce angina pectoris, or cerebral ischemia, leading to severe clinical manifestations such as heart failure, myocardial infarction (MI), cerebral infarction and lower limb ischemia and amputation [2]
D., Cui, P
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Both mouse primary cortical neurons (10 or 20 M for 3 or 6 h) and a triple-transgenic AD mouse model treated with SF (56.4 or 282 mol/kg/day for 6 days/week for 8 weeks) exhibited enhanced brain-derived neurotropic factor (BDNF) expression, crucial for neuronal survival and synaptic plasticity, suggesting a potential epigenetic mechanism for SFs neuroprotective effects (61)
PMID 19655431
