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2.2 GIPR agonism serves to reduce GLP-1R mediated GI AEs in the clinic Treatment with GLP-1R agonists can drive nausea, diarrhea, vomiting, and constipation, which often results in discontinuation of treatment (6-10% of patients) or reduction in dose (~15% of patients) (63)

When its used as an alternative: Contrave is best suited for individuals who struggle with food addiction, late-night snacking, or stress eating

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Apr 2020;11(2):95-107

Muscle preservation challenges : Weight losswithout intentional strength trainingtypically includes some muscle loss alongside fat, reducing firmness and shape