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Heart rate effects should be evaluated in the context of overall tolerability and treatment goals
Dermatol Surg
For an oral drug, the organ that receives the highest dose is the liver 50% of all drugs fail on liver toxicity Pfizer has not been so lucky
Very rarely, a person will have a serious allergic reaction to a medication, so severe symptoms should be reported to your healthcare team immediately
The short answer: GLP-1 medications (semaglutide, tirzepatide, liraglutide, and others) can change normal hydration patterns through reduced thirst signaling, slowed gastric emptying, reduced fluid intake from suppressed appetite, and GI side effects that increase fluid loss
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