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Clin Exp Allergy J Br Soc Allergy Clin Immunol
Although the central roles of mtROS, mtDNA leakage, and the NLRP3/cGAS-STING pathways in driving chronic inflammation in DW have been established, the specific regulatory networks of these events across different stages of wound healing and various cell types (such as macrophages, fibroblasts, and keratinocytes) remain unclear
Keith M, Quach S, Ahmed M, et al
Sasaninia K, Kelley M, Abnousian A, Badaoui A, Alexander L, Sheren N, Owens J, Rajurkar S, Razo-Botello B, Chorbajian A, Yoon S, Dhama S, Avitia E, Ochoa C, Yutani R, Venketaraman V
At the same time, it exhibits a favorable safety profile in animal studies
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