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B420 is the probiotic strain in the formula, and the published 6-month RCT in 225 overweight and obese adults reported a body fat mass difference of -4.0% versus placebo (P=0.002), a 2.4 cm waist circumference reduction more than placebo, and a daily energy intake reduction of approximately 300 kcal compared to placebo (post-hoc factorial analysis).[9] The trial did not select for GLP-1 users, did not measure constipation as an endpoint, and the available evidence is at the ingredient-level human evidence tier
N Engl J Med 390: 497509, 2024
Even with coverage, most plans wont pay the entire cost, which makes manufacturer savings programs a key way to lower out-of-pocket expenses
The 5mg vial also makes sense for people testing semaglutide for the first time
After 4 weeks at 0.25 mg, the dose increases to 0.5 mg weekly, then steps up every 4 weeks through 1.0 mg and 1.7 mg until reaching the 2.4 mg maintenance dose by about week 17
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