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Results Human GLP-1R -cell interactome reveals binding of agonist-stimulated GLP-1R to signalling effectors, with strong prevalence of ERMCSs-localised proteins To gain a comprehensive understanding of the specific downstream partners and signalling mediators engaged by active GLP-1Rs in pancreatic -cells, we performed an interactome analysis of proteins that bind to the receptor under vehicle versus 5-minute stimulation with the GLP-1RA exendin-4 in a subline of rat INS-1 832/3 -cells stably expressing SNAP/FLAG-tagged human GLP-1R (SNAP/FLAG-hGLP-1R)
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Obesity-related comorbid conditions include cardiovascular disease, GI disorders, metabolic syndrome, diabetes, respiratory problems, obstructive sleep apnea, musculoskeletal disorders, depression, and certain cancers
