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Around 3,800 participants were enrolled across both trials, randomized to placebo or oral semaglutide 14 mg daily for up to 104 weeks (~2 years)

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IGF-2 is composed of 67 amino acids and has growth-promoting activity similar to that of IGF-1, but its expression pattern is not controlled by growth hormone (10)

is particularly important because it directly examines semaglutide use in older adults with T2DM with an explicit focus on sarcopenia and provides relatively long-term outcomes [60]