The bigger safety concern is opportunity cost
GLP-1 medications without insurance can cost $800-$1,500 per month for brand-name versions, though compounded semaglutide options have brought costs down significantly
Between 10 and 15 percent of people taking GLP-1s are considered nonresponders, meaning that they lose less than 5 percent of their starting weight on the maximum tolerated dose
President Trump announced the popular GLP-1 weight loss drugs would soon be more accessible to millions of Americans at a cost of only $50 per month. | FOX 13 News - Tampa Bay
However, clinicians should remain vigilant for signs of excessive metabolic suppression or thyroid dysfunction, particularly in patients with pre-existing thyroid conditions or those experiencing symptoms beyond cold intolerance, such as severe fatigue, hair loss, or cognitive changes that might suggest thyroid hormone imbalance requiring investigation