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Psychiatry 12:669089

While binding to GLP-1 causes pancreatic cells to secrete insulin, in the brain, GLP-1 activates neurons in the hypothalamus, resulting in a feeling of satiation, or fullness

Animal models have demonstrated that GLP-1 RAs reduce drug-seeking behavior and attenuate conditioned place preference for substances such as alcohol, nicotine, and cocaine (32)

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GLP-1 (glucagon-like peptide-1) receptor agonists, such as semaglutide (brand names Ozempic and Wegovy) and tirzepatide (brand names Mounjaro and Zepbound), mimic a natural hormone produced in the gut