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Similarly, CRM 13180 PDX tumour tissue from mice treated with vehicle or C1-27 was homogenized in Cell lytic M buffer and 20 g of protein was incubated with CMFDA (500 nM) for 1 h

The review states that a definitive link could not be confirmed due to insufficient information about possible confounders such as pre-existing mental health problems, family history, life stressors, social and environmental factors, and use of other medications with labelling related to suicidality

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Figure 2: Changes in the histolopathological scores amongst the four experimental treatment groups

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