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For researchers designing combination protocols, this approach makes mechanistic sense but requires dose-optimization work to avoid redundant effects or unexpected interactions

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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA- c) is a small peptide comprised of 16 amino acids, which is encoded by DNA not in the nucleus, but inside the mitochondrial genome, specifically inside the gene that encodes the mitochondrial 12S ribosomal RNA

These peptides are often explored for their potential role in tissue repair, inflammation support, recovery, and joint health

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