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164 Furthermore, an isocaloric diet that moderately reduced protein intake (by 25%) was shown to trigger an unfolded protein response (UPR) that depended on IRE1 in cancer cells
The mechanisms through which GLP-1 receptor agonists may reduce inflammation are multifaceted and not yet fully understood
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A study by Newsome et al., designed to evaluate semaglutide as a potential treatment for Non-alcoholic Fatty Liver Disease (NAFLD)/Non-alcoholic Steatohepatitis (NASH), showed a dose dependent decrease in ALT levels, with maximal reductions occurring around week 28 and remaining stable thereafter [38]
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