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In the TRIUMPH-1 Phase 3 trial, participants on the maximum dose of retatrutide (12 mg) lost an average of 28.3% of their body weight after 80 weeks, and up to 30.3% after 104 weeks in the study extension
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The first and rate-limiting step of GSH synthesis is catalyzed by glutamate-cysteine ligase, which is regulated by cysteine availability at the level of transcription and translation 6
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