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For men, the drug can cause priapism a painful erection that does not go away and can damage the penis, requiring emergency treatment

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The shared biological properties of exendin-4 and human GLP-1 probably stem from their primary and secondary structures, but exendin-4 is naturally resistant to degradation by the DPP-4 enzyme, attributed to the presence of glycine at position 2, resulting in an intravenous half-life of approximately 30 minutes (85)

Surg Neurol Int 2015;6(suppl 27):S661S667