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This copper-binding motif is critical: the apo-peptide (GHK without copper) shows substantially reduced biological activity in most in vitro assays, indicating that the metal center is required for receptor interaction and downstream signaling

REDEFINE 1 ClinicalTrials.gov number, NCT05567796.) Notes This article was published on June 22, 2025, and updated on July 28, 2025, at NEJM.org

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42 The research results showed that in the PCOS group, MDA levels significantly increased, while SOD and GSH activities decreased