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Patients who received duloxetine (30 mg daily in the first week and 60 mg daily in the second week of each chemotherapy cycle) had significantly lower levels of some types of neuropathy than those who received placebo, but duloxetine had no effect on measures of numbness, tingling, burning, or cold sensitivity (Aghili 2024)

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Weight reduction decreases vertical force transmission, leading to diminished stimulation of osteoblasts and subsequent net bone resorption

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