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6 Some research suggests this may reduce how effectively oral hormones are absorbed, although the degree of impact can vary depending on the specific medication

doi: 10.1038/nchembio.2239 38 HouXLiHJieCLiuZBiXWangJet al

Heres the FDAs stance in a nutshell: Compounded drugs are permitted when there is a bona fide shortage of the FDA-approved versions, and only under specific conditions, such as when the dosages or products are not commercially available, or for particular indications unique to an individual patient

Safety considerations: The FDA continues to crack down on compounded (non-FDA-approved) semaglutide and tirzepatide products due to serious safety reports tied to misdosing and sterility issues

2 Cardiovascular Benefits: Research has shown that some GLP-1 agonists, such as liraglutide and semaglutide, reduce major adverse cardiovascular events in people with type 2 diabetes