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Finally, selective regulation within the sirtuin family is essential, as overactivation of SIRT1 could disrupt the functional balance of related sirtuins, necessitating careful control of activation intensity and tissue- or subcellular-specific delivery

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Leyden JJ, Rawlings AV

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The therapeutic effects are achieved through a combination of mechanisms: disruption of bacterial membranes via the cationic hydrogel, intracellular ROS burst during discharge, and depletion of GSH in the surrounding microenvironment to sustain oxidative stress