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Favourable changes in cardiometabolic markers were also reported in the Phase 2 trial data, including reductions in: Systolic blood pressure Triglyceride levels Waist circumference (a proxy for visceral adiposity) However, these are surrogate markers and should not be interpreted as evidence of a reduction in major adverse cardiovascular events (MACE)

However, its important to note that the evidence supporting their effectiveness is weak at best

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For researchers comparing GH-axis compounds, the MK-677 Ibutamoren research guide covers the orally bioavailable GHSR agonist alternative, which can substitute for Ipamorelin in research protocols where oral administration is preferred

Vets may use physical examination, gum color check, blood tests, stool tests, medication history, abdominal X-rays, ultrasound, or endoscopy depending on the dogs signs