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[42] Psychosis rarely arises from therapeutic use

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In sum, a host of pharmacologic agents from novel small molecules to repurposed anesthetic drugs are being utilized to stabilize mitochondria, reduce DAMPs release, and optimize immune cell metabolism during the perioperative period

The ROS burst precipitates mitochondrial Ca 2+ overload through activation of the mitochondrial calcium uniporter (MCU), further depolarizing m and triggering opening of the mPTP