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No oral semaglutide
The inclusion criteria encompassed English-language publications or publications with an English translation available, including conference abstracts, observational studies, randomized controlled trials (RCTs) and meta-analyses
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Use within 23 months after opening
In adjusted analyses, semaglutide reduced epigenetic aging across multiple second- and third-generation clocks, including PhenoAge ( 4.9 years/year, p = 0.004), PCGrimAge ( 3.1, p = 0.007), GrimAge V2 ( 2.3, p = 0.009), OMICmAge ( 2.2, p = 0.009), RetroAge ( 2.2, p = 0.030), and DunedinPACE ( 0.09 units, 9% slower, p = 0.01)
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