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A TEST OF THE SAME DOSE OF A FINE AND A COARSE AEROSOL IN DOG SURPRISINGLY INDICATED NEGLIGIBLE INTRANASAL FILTRATION Mikael Brlls 1, Steven Oag1 & Eva Lamm Bergstrm1 1AstraZeneca BioPharmaceuticals R&D, AstraZeneca R&D Gothenburg, Mlndal, SE431 83, Sweden Summary: A novel inhalation exposure system was developed to increase the efficiency of pharmacokinetic (PK) evaluations of inhaled drugs in a large species such as the dog by enabling simultaneous administration of multiple drugs to the same animal in a single experiment, facilitating a direct comparison of the same lung dose of different drugs using the same blood samples, which can be considered to be a refinement measure from an animal research perspective
This designation permits the use of research materials strictly for in vitro laboratory testing and analytical experimentation
Kaner Z, Engelman R, Schuster R, et al
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