Microbiome 16S V1-V3 rRNA gene sequencing, alignment, and initial filtering were performed by BGI
Intriguingly, genetic variations with reduced IIS due to SNPs of interacting components of the IIS cascades ( GH1, IGF1, IGF1R, IRS1, FoxO1A, FoxO3A ) and have been associated with increased longevity [30, 31]
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The skin is chronically exposed to both endogenous and environmental pro-oxidants leading to the production of ROS.[] ROS leads to lipid peroxidation, which is considered as the hallmark of oxidative stress in body.[] Malondialdehyde (MDA) is considered as the end product of lipid peroxidation and MDA levels is directly proportional to the oxidative stress.[] The most important antioxidants present in human body include superoxide dismutase, glutathione peroxidase, and catalase.[] Glutathione which is considered a master antioxidant can help keep the balance between the oxidant and antioxidant system in the body and prove to be an effective therapy but studies proving its efficacy are limited