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Notably, understanding these microbiome changes is essential for elucidating tumour progression mechanisms, development of specific biomarker strategies and optimising therapeutic approaches, potentially contributing to improved clinical management of the disease

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These protocols recapitulate key cues of pancreatic development and typically involve multistep differentiation procedures

The effect size observed across all studies is consistently impressive, typically 3040% in the RCTs [7,8,9, 23] and 4050% in the RWE studies [16, 24, 25]