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Countries like Madagascar and Burundi report high DALYs at 216.8 per 100,000 and 169.3 per 100,000, respectively
Common gastrointestinal side effects occur in many patients and include: Nausea (most common, typically improving after 4-8 weeks) Vomiting Diarrhea Constipation Abdominal pain or discomfort Decreased appetite These effects result from the drugs' mechanism of actionslowing gastric emptying and affecting gut motilityrather than indicating tissue damage or malignancy
Not strictly required, but 10 to 15 minutes of sun exposure during loading significantly accelerates results
Clinical supervision supports safe titration, and consistent titration practices help maintain treatment stability over time
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