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However, for those with mild dietary deficiencies and intact absorption mechanisms, high-dose oral tablets can often be sufficient, albeit with potentially slower results

Nausea, vomiting, diarrhea, and constipation are common, especially in the early weeks of treatment

Additionally, DSIP appears to be regulated by glucocorticoids, and its signaling may interact with the MAPK cascade through homology with glucocorticoid-induced leucine zipper (GILZ), suggesting potential roles in cellular stress responses

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Ethics declarations Competing interests MCM: Bayer (consultant), Roche (consultant, speaker), and SJJ Solutions (consultant, royalties, speaker)