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As discussed above, sufficient levels of thiamine in the brain are supported at the expense of other tissues, causing TD in these other tissues long before the TD occurs in the brain
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GLP-1 receptor agonists such as Saxenda and Wegovy work, with clinical trial evidence behind them roughly 6% and 16% body weight reduction respectively over 68-week trials
Single-cell, omics studies of human L-cells, which secrete GLP-1 and 2, may uncover regulatory networks controlling incretin secretion
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