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Semaglutide has 94% sequence homology with native GLP-1 and three key structural differences that provide extended pharmacokinetics [16] (Fig
it is not a peptide
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Berberine has shown promise in some trials for improving glycaemic control in type 2 diabetes, with mechanisms possibly involving improved insulin sensitivity and altered gut microbiota
Each freeze-thaw cycle creates ice crystals that can physically disrupt peptide structure, and the process concentrates the peptide at the boundary between frozen and unfrozen regions, potentially causing aggregation
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