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doi: 10.3390/nu17091568 7 CaiR.XiaoY.XingJ.YuK.LiX.ChaiY

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Flavonoids can be summarized to reverse MDR via multiple mechanisms such as regulating the ABC transporters, boosting ROS production in cancer cells, or conversely inhibiting the activities of the anti-oxidative enzymes, subduing the proliferation of cancer stem cells, inhibiting EMT (epithelialmesenchymal transition) signalling, modulating autophagy and the related factors, and lastly, by distorting the progression of cell cycle in cancer cells [202]

Furthermore, F 405 /F 488 is insensitive to other environmental factors, including potential non-specific interactions or reactions with intracellular proteins (Fig