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The unfortunate truth is that big risk signals (lets say the kind you get from drinking antifreeze) can be spotted from the anecdotal experience of people in the world just trying things, but small-but-serious risk signals (lets say cardiovascular disease with tofacitinib) are really hard to identify without a proper trial or a proper observational study
References Gironi, M., C
These are the glue that keeps the gut lining and vascular barriers intact, which is why it is often cited in discussions regarding leaky gut and systemic inflammation
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