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Determination of LongR3-IGF-I, R3-IGF-I, Des13 IGF-I and their metabolites in human plasma samples by means of LCMS
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Speculated biological plausibility for the sex difference include differences in body weight at baseline, which might lead to greater average drug exposures among women compared to men, and the potential interaction of semaglutide with sex hormones that play a role in appetite regulation (e.g., estrogen)
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